There is setting in winecfg in current version but it have strangely low maximum limit so it is useless in most cases. This is how I do it. Execute to make sure that WINE is really closed (if you forgot this step then registry changes may "magically" disappear): wineserver -k Now open registry with your favorite editor. I like nano, but you can use kwrite or any other you like: nano ~/.wine/system.reg Search for "LogPixels" there. You will see something like this: "LogPixels"=dword:00000060 Change 60 to something more suitable. For example this is what I use with my two displays (one with resolution 1680x1050 and another one with 1280x1024): "LogPixels"=dword:00000095 Save the registry. Now you can try to launch notepad to see the result: wine notepad If you don't like the result repeat all steps. If you like it then you're done.
source : http://www.winehq.org/pipermail/wine-users/2007-October/027896.html
