Q n A : how to repaire wine in debian

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winecfg wine 10

Common Repair Methods for Wine on Debian

• Reset the Wine Prefix (Easiest Fix): If applications are crashing, the configuration folder is likely corrupted. Back it up and remove it to force a fresh configuration:
  • mv ~/.wine ~/.wine.bak
  • winecfg (This will recreate the folder)
• Reinstall and Purge: If Wine itself is broken, completely remove it and reinstall:
  • sudo apt-get purge wine*
  • sudo apt-get autoremove
  • sudo apt-get install wine
• Fix Dependency Errors (Debian 12+): If wine32:i386 errors occur, ensure 32-bit architecture is enabled and install the necessary libraries:
• sudo dpkg --add-architecture i386
• sudo apt update
• sudo apt install wine32

Configuring Wine

• To open the Wine configuration window, enter the following command:

  winecfg

• To open the Wine registry editor, enter the following command:

  regedit

Installing and removing Windows programs

• In order to install a program, launch the Windows installation file (.exe/.msi) with the following command:

wine setup.exe

• In order to remove a program, launch the wine uninstaller with the following command:

wine uninstaller

Additional programs for Wine

winetricks  is a helper script to download and install various redistributable 
runtime libraries needed to run some programs in Wine. These may include
replacements for components of Wine using closed source libraries. 
To download and install, enter: 
sudo apt install winetricks

Other reference link here 
step by step how to install wine in debian 12 from 0 to completed